History of Kyorin Group

We have unceasingly strived to realize our corporate philosophy of always making a contribution to human health.
Kyorin will continue to take on challenges and will evolve to become a company supporting healthy lifestyles through our business in the treatment and prevention of disease and the maintenance and promotion of good health.

Company history

Product history

1920

1923

Toyo Shinyaku Sha, the predecessor of KYORIN Pharmaceutical Co., Ltd., was founded.

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1931

Kyorin Chemical Laboratory was established.

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1940

Kyorin Chemical Laboratory was renamed KYORIN Pharmaceutical Co., Ltd., and Kyorin Yakuhin Co., Ltd. was organized as an independent marketing division.

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1947

The Okaya Plant was started

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1950

1957

The medical journal bulletin “Doctor Salon” was started.

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1961

Behyd, a diuretic and antihypertensive agent, was launched.

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1962

Kyorin Chemical Laboratory (later Technical Center of Development) was established.

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1965

The Head Office was completed in Kanda Surugadai.

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1965

KYORIN AP-2, an analgesic, was launched.
Deamelin-S, an oral hypoglycemic agent, was launched.

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1967

The Nogi Plant was opened.

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1971

Cholexamin, a lipid metabolism and peripheral circulation improving agent, was launched.

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1974

Hespander, a plasma substitute and extracorporeal circulation flow improver, was launched.

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1977

Central Research Laboratories were opened.

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1980

1980

Norfloxacin (NFLX), an antibacterial agent, was licensed to Merck & Co. (U.S.A.).

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1981

Mucodyne, a mucoregulant, was launched.

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1984

Baccidal (NFLX), a broadspectrum oral antibacterial agent, was launched.

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1989

Ketas, for bronchial asthma and cerebrovascular disorders, was launched.
Baccidal Eyedrops, a broadspectrum ophthalmic antibacterial agent, was launched.

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1992

KYORIN Pharmaceutical Co., Ltd. and Kyorin Yakuhin Co., Ltd. were merged, and the new KYORIN Pharmaceutical Co., Ltd. was founded.

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1993

Megalocin (FLRX), a long-acting new quinolone agent, was launched.

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1995

The Noshiro Plant was opened.

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1996

A joint venture, Nisshin KYORIN Pharmaceutical Co., Ltd., was established with Kyorin’s capital participation.
The Research Center (now the WATARASE Research Center) was founded.

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1996

Pentasa, a treatment for ulcerative colitis and Crohn’s disease, was launched.

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1996

Gatifloxacin (GFLX) was licensed to Bristol-Myers Squibb (U.S.A.).

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1998

Milton, an effervescent disinfectant business, was acquired from P&G.

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1999

Listed on the Tokyo Stock Exchange, Second Section.

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2000

Listed on the Tokyo Stock Exchange, First Section.

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2000

2000

Gatifloxacin eyedrops was licensed to Allergan (U.S.A.).

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2001

A subsidiary company, Kyorin USA, Inc. (U.S.A.), was established.

2001

Kipres, the leukotriene receptor antagonist and bronchial asthma treatment medicine, was launched.

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2002

A subsidiary company, Kyorin Europe GmbH (Germany), was established.

2002

Gatiflo (GFLX), a broad-spectrum, oral antibacterial agent, was launched.

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2004

ActivX Biosciences, Inc. (U.S.A.) became a wholly owned subsidiary.

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2005

The stock of Toyo Pharma Co., Ltd. (present KYORIN Rimedio Co., Ltd.) was acquired, making it into a subsidiary company.

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2006

The Nogi Plant was closed.

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2006

The Kyorin Group shifts to a holding company structure through a share exchange with KYORIN Co., Ltd.

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2007

Uritos Tablets 0.1 mg, an overactive bladder drug, was launched.

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2008

KYORIN Pharmaceutical merged with Nissin Kyorin Pharmaceutical.

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2010

KYORIN Co., Ltd. changed its name to KYORIN Holdings, Inc.

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2010

2012

Acquisition (conversion into subsidiary) of the Shiga Plant of MSD K.K. and established KYORIN Pharmaceutical Facilities Co., Ltd.

2012

RUBYSTA, a multi-purpose disinfectant cleaner, was launched.

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2013

Head office moved to Ochanomizu sola city in Kanda Surugadai.

2013

Flutiform, a combination drug for asthma treatment, was launched.

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2015

Establishment of the WATARASE Research Center of KYORIN Pharmaceutical Co., Ltd. through consolidation of the Drug Discovery Center (the former Central Research Laboratories) and the R&D Center (the former Research Center).

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2015

Eklira Genuair, a treatment for COPD, was launched.
FPR2 agonist program was licensed to Bristol-Myers Squibb Company (U.S.A.)

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2016

The Okaya Plant was closed

2016

Montelukast tablets 10mg, 5mg「KM」, the leukotriene receptor antagonist and bronchial asthma treatment medicine, was launched.
DESALEX Tablets 5mg a treatment of allergic diseases drug was launched

photo: Montelukast

2017

KYORIN Rimedio Co., Ltd.’s Takaoka Pharmaceutical Technology Innovation Center was established.

2018

New manufacturing subsidiary, KYORIN Pharmaceutical Group Facilities Co., Ltd. (head office: Tokyo), commences operations.

2018

Beova Tablets 50mg a treatment of OAB drug was launched

photo: Beova Tablets 50mg

2019

GeneSoC®, a microchannel-based genetic measurement device, was launched.

photo: GeneSoC®

2020

KYORIN Pharmaceutical Group Facilities Co., Ltd. and KYORIN Medical Supply Co., Ltd. merge.

2020

Lasvic Tablets 75mg an oral quinolone antibacterial agent was launched

photo: Lasvic Tablets 75mg

2021

Lasvic Intravenous Drip Infusion Kit 150mg an injectable new quinolone antibacterial agent was launched

photo: Lasvic Intravenous Drip Infusion Kit 150mg

Zymso Intravesical Solution 50%, an interstitial cystitis treatmet was launched

photo: Zymso Intravesical Solution 50%

GeneSoC® mini was launched.

photo: GeneSoC® mini

2022

Lyfnua® Tablets 45mg Selective P2X3 receptor antagonist/Refractory chronic cough was launched

photo: Lyfnua® Tablets 45mg Selective P2X3 receptor antagonist/Refractory chronic cough